ML-TTAathira Bold is a Bold TrueType Font. It has been downloaded 3478 times. 2 users have given the font a rating of 4.5 out of 5. You can find more information about ML-TTAathira Bold and it's character map in the sections below. Please verify that you're a human to download the font for free.
ML-TTAathira Bold is a beautiful Malayalam Font. This font is one of the most famous fonts in India. You can use this font for both your personal and professional use. You can use this traditional font to make your work look great. This is a Bold TrueType Font. And the subfamily it belongs to is bold.
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We defined 7 distinct body parts or segments on the larvae by grouping the 49 skeleton points. Initially, we identified a point in the range of 4 to 22 along the skeleton where the contour width decreases sharply (local minima of the derivative of contour width along the skeleton) and defined it as the neck point. The change in contour width is characteristic of the neck, where the wide head region ends and the narrower tail of the larvae starts. The neck segment is defined such that it comprises 3 skeleton points with the neck point as the center. The points on the skeleton that lie anterior to this segment are hence grouped into a head segment, and the coordinates that lie after are grouped into a tail segment. The skeleton points tail segment is further divided into 5 segments, namely tail_base (TB), tail_pre_mid (TprM), tail_mid (TM), tail_post_mid (TpoM), and tail_tip (TT), such that a summary of movement of the tail can be obtained without limiting the degrees of freedom.
Dementia is also associated with a variety of pathophysiological facets, including mitochondrial dysfunction, excitotoxicity, neuroinflammation, and oxidative stress [4, 5]. Herein, we provided evidence that positive modulation of HGF/MET by fosgo-AM confers protection to cortical neurons challenged with neurotoxic insults that mimic critical aspects of neurodegeneration: MPP+, glutamate, LPS, and H2O2. MPP+ is a potent inhibitor of mitochondria complex I that induces ATP depletion, breakdown of the electron transport chain, generation of reactive oxidative species (ROS), caspase-3 activation, and subsequent apoptosis [53, 54]. Glutamate excitotoxicity is a pathological hallmark of neurodegeneration in which excessive and prolonged activation of glutamatergic signaling leads to intracellular Ca2+ overload, loss of mitochondrial membrane potential, oxidative stress, and eventually cell death [55]. LPS is a potent activator of toll-like receptor 4 (TLR4), which is expressed on neurons and microglia, and can initiate a series of proinflammatory pathways. For example, LPS induces strong release of TNF-α and IL-6, both of which are key proinflammatory mediators that lead to neuronal damage [56, 57]. H2O2 is a significant source of free radicals, directly elevating levels of ROS [58]. These neurodegenerative components are not mutually exclusive. Instead, they exist in a positive feedback loop that creates an ongoing cycle of mitochondrial damage, ROS production, neuroinflammation, excitotoxicity, and neuronal damage. In this regard, the ability of fosgo-AM to protect neurons from all tested insults highlights its ability to not only directly mitigate several cellular stressors, but also potentially interrupt the neurodegenerative cascade as a whole. Although the molecular mechanisms downstream of HGF/MET by which fosgo-AM confers protection to these various insults are not yet elucidated, a plausible explanation may lie in its ability to activate prosurvival signaling cascades mediated by ERK and/or AKT that promote induction of neuroprotective genes to counteract cell death.
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